Vrije Universiteit Brussel

 

Welcome at the Research Unit BETA CELL NEOGENESIS (BENE)


Harry Heimberg
Mark Van de Casteele
Coordinator and Principal Investigator
co-Principal Investigator

 

 
A decreased beta cell mass or the incapability of the beta cell mass to compensate for increased insulin needs, results in an absolute (type I) or relative (type II) deficiency of insulin defining type I and type II diabetes, respectively. Our research group aims to compensate the reduced beta cell mass in diabetes by transplantation or in situ differentiation and expansion of beta- and pre-beta cells.

We therefore investigate mechanisms to generate new, fully functional beta cells by:

Differentiation of endogenous progenitor/stem cells and regeneration of the beta cell mass
Protection and proliferation of existing beta cells
Transdifferentiation of pancreatic non-beta cells to beta cells



Our research is performed within the collaborative framework of the JDRF Center for Beta Cell Therapy in Diabetes and IMIDIA.



Latest update: 3 July 2016

© 2008 • BENE • Vrije Universiteit Brussel • Faculteit Geneeskunde & Farmacie • Laarbeeklaan 103 • 1090 Jette •
Tel.: 02/477.44.69 • Fax.: 02/477.44.72 • bene@vub.ac.be