Vrije Universiteit Brussel

 

 

 

Publications

2017

Liu KC, Leuckx G, Sakano D, Seymour PA, Mattsson CL, Rautio L, Staels W, Verdonck Y, Serup P, Kume S, Heimberg H, Andersson O: Inhibition of Cdk5 Promotes β-cell Differentiation from Ductal Progenitors.
Diabetes 2017 Oct 6. pii: db161587. doi: 10.2337/db16-1587. [Epub ahead of print]
PubMed Abstract

Hilbrands R, Keymolen K, Michotte A, Marichal M, Cools F, Goossens A, Veld PI, De Schepper J, Hattersley A, Heimberg: Pancreas and gallbladder agenesis in a newborn with semilobar holoprosencephaly, a case report.
BMC Med Genet 18(1):57, 2017
PubMed Abstract

Ben-Othman N, Vieira A, Courtney M, Record F, Gjernes E, Avolio F, Hadzic B, Druelle N, Napolitano T, Navarro-Sanz S, Silvano S, Al-Hasani K, Pfeifer A, Lacas-Gervais S, Leuckx G, Marroquí L, Thévenet J, Madsen OD, Eizirik DL, Heimberg H, Kerr-Conte J, Pattou F, Mansouri A, Collombat P: Long-Term GABA Administration Induces Alpha Cell-Mediated Beta-like Cell Neogenesis.
Cell 168(1-2):73-85, 2017
PubMed Abstract

Staels W, Heremans Y, Leuckx G, Van Gassen N, Salinno C, De Groef S, Cools M, Keshet E, Dor Y, Heimberg H, De Leu N: Conditional islet hypovascularisation does not preclude beta cell expansion during pregnancy in mice.
Diabetologia Epub ahead of print, 2017
PubMed Abstract

Cunha JP, Leuckx G, Sterkendries P, Korf H, Bomfim-Ferreira G, Overbergh L, Vaes B, Heimberg H, Gysemans C, Mathieu C: Human multipotent adult progenitor cells enhance islet function and revascularisation when co-transplanted as a composite pellet in a mouse model of diabetes.
Diabetologia 60(1):134-142, 2017
PubMed Abstract

2016

Staels W, De Groef S, Bussche L, Leuckx G, Van de Casteele M, De Leu N, Baeyens L, Heremans Y, Heimberg H. Making beta(-like)-cells from exocrine pancreas.
Diabetes Obes Metab 18: Suppl 1:144-151, 2016
PubMed Abstract

De Groef S, Renmans D, Cai Y, Leuckx G, Roels S, Staels W, Gradwohl G, Baeyens L, Heremans Y, Martens GA, De Leu N, Sojoodi M, Van de Casteele M, Heimberg H: STAT3 modulates β-cell cycling in injured mouse pancreas and protects against DNA damage.
Cell Death Dis 7(6):e2272, 2016
PubMed Abstract

Lemper M, De Groef S, Stangé G, Baeyens L, Heimberg H:A combination of cytokines EGF
and CNTF protects the functional beta cell mass in mice with short-term hyperglycaemia.
Diabetologia 59(9):1948-1958, 2016
PubMed Abstract

Lima MJ, Muir KR, Docherty HM, McGowan NW, Forbes S, Heremans Y, Heimberg H, Casey J, Docherty K: Generation of Functional Beta-Like Cells from Human Exocrine Pancreas.
PLoS One 11(5):e0156204, 2016
PubMed Abstract

Sojoodi M, Stradiot L, Tanaka K, Heremans Y, Leuckx G, Besson V, Staels W, Van de Casteele M, Marazzi G, Sassoon D, Heimberg H, Bonfanti P: The zinc finger transcription factor PW1/PEG3 restrains murine beta cell cycling.
Diabetologia 59(7):1474-1479, 2016
PubMed Abstract

De Groef S, Staels W, Van Gassen N, Lemper M, Yuchi Y, Sojoodi M, Bussche L, Heremans Y, Leuckx G, De Leu N, Van de Casteele M, Baeyens L, Heimberg H: Sources of beta cells inside the pancreas.
Diabetologia 59(9):1834-1837, 2016
PubMed Abstract

Mfopou JK, Houbracken I, Wauters E, Mathijs I, Song I, Himpe E, Baldan J, Heimberg H, Bouwens L: Acinar phenotype is preserved in human exocrine pancreas cells cultured at low temperature: implications for lineage-tracing of β-cell neogenesis.
Biosci Rep 36(3). pii: e00329. doi: 10.1042/BSR20150259, 2016
PubMed Abstract

2015

Staels W, Heremans Y, Heimberg H: Reprogramming of human exocrine pancreas cells to beta cells.
Best Pract Res Clin Endocrinol Metab 29:849-857, 2015
PubMed Abstract

Muir KR, Lima MJ, Docherty HM, McGowan NW, Forbes S, Heremans Y, Forbes SJ, Heimberg H, Casey J, Docherty K: Krüppel-Like Factor 4 Overexpression Initiates a Mesenchymal-to-Epithelial Transition and Redifferentiation of Human Pancreatic Cells following Expansion in Long Term Adherent Culture.
PLoS One 10:e0140352, 2015
PubMed Abstract

Staels W, De Groef S, Heremans Y, Coppens V, Van Gassen N, Leuckx G, Van de Casteele M, Van Riet I, Luttun A, Heimberg H, De Leu N: Accessory cells for β-cell transplantation.
Diabetes Obes Metab 18:115-124, 2015
PubMed Abstract

De Groef S, Leuckx G, Van Gassen N, Staels W, Cai Y, Yuchi Y, Coppens V, De Leu N, Heremans Y, Bayens L, Van de Casteele M, Heimberg H: Surgical injury to the mouse pancreas through ligation of the pancreatic duct as a model for endocrine and exocrine reprogramming and proliferation.
J Vis Exp Aug 7;(102):e52765, 2015
PubMed Abstract

Khosravi-Maharlooei M, Hajizadeh-Saffar E, Tahamtani Y, Basiri M, Montazeri L, Khalooghi K, Kazemi Ashtiani M, Farrokhi A, Aghdami N, Sadr Hashemi Nejad A, Larijani MB, De Leu N, Heimberg H, Luo X, Baharvand H: THERAPY OF ENDOCRINE DISEASE: Islet transplantation for type 1 diabetes: so close and yet so far away.
Eur J Endocrinol 173:R165-183, 2015
PubMed Abstract

Yuchi Y, Cai Y, Legein B, De Groef S, Leuckx G, Coppens V, Van Overmeire E, Staels W, De Leu N, Martens G, Van Ginderachter JA, Heimberg H, Van de Casteele M: Estrogen Receptor α Regulates β-Cell Formation During Pancreas Development and Following Injury.
Diabetes 64:3218-3228, 2015
PubMed Abstract

Bonfanti P, Nobecourt-Dupuy E, Oshima M, Albagli-Curiel O, Stangé G, Sojoodi M, Heremans Y, Heimberg H, Scharfmann R: Epidermal Growth Factor controls expansion and endocrine differentiation of human and mouse fetal pancreas progenitors.
Stem Cells Dev 24:1766-1778, 2015
PubMed Abstract

Van Gassen N, Staels W, Van Overmeire E, De Groef S, Sojoodi, S, Heremans Y, Leuckx G, Van de Casteele M, Van Ginderachter J, Heimberg H, De Leu N: Macrophages: versatile gatekeepers during pancreatic beta cell development, injury and regeneration.
Stem Cell Transl Med 4:555-563, 2015
PubMed Abstract

Hajizadeh-Saffar E, Tahamtani Y, Aghdami N, Azadmanesh K, Habibi-Anbouhi M,
Heremans Y, De Leu N, Heimberg H, Ravassard P, Shokrgozar M, Baharvand H: Inducible VEGF Expression by Human Embryonic Stem Cell-Derived Mesenchymal Stromal Cells Reduces the Minimal Islet Mass Required to Reverse Diabetes.
Sci Rep 5:9322, 2015
PubMed Abstract

Van Gassen N, Van Overmeire E, Leuckx G, Heremans Y, De Groef S, Cai Y, Elkrim Y, Gysemans C, Stijlemans B, Van de Casteele M, De Baetselier P, De Leu N, Heimberg H, Van Ginderachter J: Macrophage dynamics are regulated by local macrophage proliferation and monocyte recruitment in injured pancreas.
Eur J Immunol 45:1482-1493, 2015
PubMed Abstract

Lemper M, Leuckx G, Heremans Y, German MS, Heimberg H, Bouwens L, Baeyens L: Reprogramming of human pancreatic exocrine cells to β-like cells.
Cell Death Differ 22:1117-1130, 2015
PubMed Abstract

Sangan CB, Jover R, Heimberg H, Tosh D: In vitro reprogramming of pancreatic alpha cells towards a beta cell phenotype following ectopic HNF4α expression.
Mol Cell Endocrinol 399:50-59, 2015
PubMed Abstract

Ding L, Heremans Y, Pipeleers D, Ling Z, Heimberg H, Gysemans C, Mathieu C: Clinical Immunosuppressants Inhibit Inflammatory, Proliferative And Reprogramming Potential, But Not Angiogenesis Of Human Pancreatic Duct Cells.
Cell Transplant 24:1585-1598, 2015
PubMed Abstract

2014

Ding L, Gysemans CA, Stangé G, Heremans Y, Yuchi Y, Takiishi T, Korf H, Chintinne M, Carr RD, Heimberg H, Pipeleers D, Mathieu C: Combining MK626, a Novel DPP-4 Inhibitor, and Low-Dose Monoclonal CD3 Antibody for Stable Remission of New-Onset Diabetes in Mice.
PLoS One 9:e107935, 2014
PubMed Abstract

Van de Casteele M, Leuckx G, Cai Y, Yuchi Y, Coppens V, De Groef S, Van Gassen N, Baeyens L, Heremans Y, Wright CV, Heimberg H: Partial duct ligation: β-cell proliferation and beyond.
Diabetes 63:2567-2577, 2014

Paganelli M, Nyabi O, Sid B, Evraerts J, El Malmi I, Heremans Y, Dollé L, Benton C, Calderon PB, van Grunsven L, Heimberg H, Campard D, Sokal E, Najimi M: Downregulation of Sox9 expression associates with hepatogenic differentiation of human liver mesenchymal stem/progenitor cells.
Stem Cells Dev 23:1377-1391, 2014
PubMed Abstract

Cai Q, Bonfanti P, Sambathkumar R, Vanuytsel K, Vanhove J, Gysemans C, Debiec-Rychter M, Raitano S, Heimberg H, Ordovas L, Verfaillie CM: Prospectively isolated NGN3-expressing progenitors from human embryonic stem cells give rise to pancreatic endocrine cells.
Stem Cells Transl Med 3:489-499, 2014
PubMed Abstract

De Leu N, Heremans Y, D'Hoker J, Cai Y, Coppens V, Van Gassen N, Magenheim J, Salpeter S, Swisa S, Khalaileh A, Van de Casteele M, Keshet E, Dor Y, Heimberg H: Short-term overexpression of VEGF-A in beta cells indirectly stimulates their proliferation and protects against diabetes.
Diabetologia 57:140-147, 2014
PubMed Abstract

Baeyens L, Lemper M, Leuckx G, De Groef S, Bonfanti P, Stangé G, Shemer R, Nord C, Scheel D, Pan F, Alhgren U, Gu G, Stoffers D, Dor Y, Ferrer J, Gradwohl G, Wright C, Van de Casteele M, German M, Bouwens L, Heimberg H: EGF andCNTF together regenerates the functional beta cell mass in mice with long-term diabetes by acinar cell reprogramming.
Nat Biotechnol 32:76-83, 2014
PubMed Abstract

2013

Coppens V, Heremans Y, Leuckx G, Suenens K, Jacobs-Tulleneers-Thevissen D, Verdonck K, Luttun A, Heimberg H, De Leu N: Reversal of hyperglycaemia in diabetic mice by a marginal islet mass together with human blood outgrowth endothelial cells is independent of the delivery technique and blood clot-induced processes.
Islets 5:196-200, 2013
PubMed Abstract

Courtney M, Gjernes E, Druelle N, Ravaud C, Vieira A, Ben-Othman N, Pfeifer A, Avolio F, Leuckx G, Lacas-Gervais S, Hecksher-Sorensen J, Ravassard P, Heimberg H, Mansouri A, Collombat P: Inactivation of Arx in pancreatic alpha cells triggers their neogenesis and conversion into functional beta-like cells.
PLoS Genet 2013
PubMed Abstract

Huch M, Bonfanti P, Boj SF, Sato T, Loomans CJ, van de Wetering M, Sojoodi M, Li VS, Schuijers J, Gracanin A, Ringnalda F, Begthel H, Hamer K, Mulder J, van Es JH, de Koning E, Vries RG, Heimberg H, Clevers H: Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis.
EMBO J 32:2708-2721, 2013
PubMed Abstract

Van de Casteele M, Cai Y, Leuckx G, Heimberg H: Mouse beta cell proliferation is inhibited by thymidine analogue labelling.
Diabetologia 56:2647-2650, 2013
PubMed Abstract

D'Hoker J, De Leu N, Heremans Y, Baeyens L, Minami K, Ying C, Lavens A, Chintinne M, Stangé G, Magenheim J, Swisa A, Martens G, Pipeleers D, Van de Casteele M, Seino S, Keshet E, Dor Y, Heimberg H: Conditional hypovascularization and hypoxia in islets does not overtly influence adult beta cell mass and function.
Diabetes 62:4165-4173, 2013
PubMed Abstract

Al-Hasani K, Pfeifer A, Courtney M, Ben-Othman N, Gjernes E, Vieira A, Druelle N, Avolio F, Ravassard P, Leuckx G, Lacas-Gervais S, Ambrosetti D, Benizri E, Hecksher-Sorensen J, Gounon P, Ferrer J, Gradwohl G, Heimberg H, Mansouri A, Collombat P: Adult duct-lining cells can reprogram into β-like cells able to counter repeated cycles of toxin-induced diabetes.
Dev Cell 26:86-100, 2013
PubMed Abstract

Kumar A, Lo Nigro A, Gysemans C, Cai Q, Esquerra C, Nelson-Holte M, Heremans Y, Jimenez-Gonzalez M, Porciuncula A, Mathieu C, Binas B, Heimberg H, Prosper F, Hering B, Verfaillie C, Barajas M: Reversal of hyperglycemia by insulin-secreting rat bone marrow- and blastocyst-derived hypoblast stem cell-like cells.
Plos One 9:e63491, 2013
PuSMed Abstract

Lima M, Muir K, Docherty H, Drummond R, McGowan N, Forbes S, Heremans Y, Houbracken I, Ross J, Forbes S, Ravassard P, Heimberg H, Casey J, Docherty K: Suppression of Epithelial to Mesenchymal Transitioning (EMT) Enhances Ex Vivo Reprogramming of Human Exocrine Pancreatic Tissue towards Functional Insulin Producing β-Like Cells.
Diabetes 62:2821-33, 2013
PubMed Abstract

Van de Casteele M, Leuckx G, Baeyens L, Cai Y, Yuchi Y, Coppens V, De Groef S, Eriksson M, Svensson C, Ahlgren U, Ahnfelt-Ronne J, Madsen O, Waisman A, Dor Y, Jensen J, Heimberg H: Neurogenin 3+ cells contribute to β-cell neogenesis and proliferation in injured adult mouse pancreas.
Cell Death Dis 2013 Mar 7;4:e523
PubMed Abstract

Pan F, Bankaitis E, Boyer D, XuX, Van de Casteele M, Magnuson M, Heimberg H, Wright C: Spatiotemporal patterns of multipotentiality in Ptf1a-expressing cells during pancreas organogenesis and injury-induced facultative restoration.
Development 140:751-764, 2013
Pubmed Abstract

Coppens V, Heremans Y, Leuckx G, Suenens K, Jacobs-Tulleneers-Thevissen D, Verdonck K, Lahoutte T, Luttun A, Heimberg H, De Leu N: Human blood outgrowth endothelial cells improve islet survival and function when co-transplanted in a mouse model of diabetes.
Diabetologia 56:382-390, 2013
PubMed Abstract

2012

Houbracken I, Baeyens L, Ravassard P, Bouwens L: Gene delivery to pancreatic exocrine cells in vivo and in vitro.
BMC Biotechnol 2012 Oct 22;12:74
PubMed Abstract

Grouwels G, Vasylovska S, Olerud J, Leuckx G, Ngamjariyawat A, Yuchi Y, Jansson L, Van de Casteele M, Kozlova EN, Heimberg H: Differentiating neural crest stem cells induce proliferation of cultured rodent islet beta cells.
Diabetologia 55:2016-2025, 2012
PubMed Abstract

Swales N, Martens GA, Bonné S, Heremans Y, Borup R, Van de Casteele M, Ling Z, Pipeleers D, Ravassard P, Nielsen F, Ferrer J, Heimberg H: Plasticity of adult human pancreatic duct cells by neurogenin3-mediated reprogramming.
PLoS One:7, e37055, 2012
PubMed Abstract

Prévot PP, Simion A, Grimont A, Colletti M, Khalaileh A, Van den Steen G, Sempoux C, Xu X, Roelants V, Hald J, Bertrand L, Heimberg H, Konieczny SF, Dor Y, Lemaigre FP, Jacquemin P: Role of the ductal transcription factors HNF6 and Sox9 in pancreatic acinar-to-ductal metaplasia.
Gut 61:1723-1732, 2012
PubMed Abstract

2011

Hald J, Galbo T, Rescan C, Radzikowski L, Sprinkel AE, Heimberg H, Ahnfelt-Rønne J, Jensen J, Scharfmann R, Gradwohl G, Kaestner KH, Stoeckert C Jr, Jensen JN, Madsen OD: Pancreatic islet and progenitor cell surface markers with cell sorting potential.
Diabetologia 55:154-65, 2011
PubMed Abstract

Martens GA, Jiang L, Hellemans KH, Stangé G, Heimberg H, Nielsen FC, Sand O, Van Helden J, Gorus FK, Pipeleers DG: Clusters of conserved Beta cell marker genes for assessment of Beta cell phenotype.
PLoS One 6:e24134, 2011
PubMed Abstract


Houbracken I, de Waele E, Lardon J, Ling Z, Heimberg H, Rooman I, Bouwens L: Lineage tracing evidence for transdifferentiation of acinar to duct cells and plasticity of human pancreas.
Gastroenterology 141:731-741, 2011
PubMed Abstract

2010

Collombat P, Xu X, Heimberg H, Mansouri A: Pancreatic beta-cells: from generation to regeneration.
Semin Cell Dev Biol 21: 838-844, 2010
PubMed Abstract

van Arensbergen J, Garcia-Hurtado J, Moran I, Maestro MA, Xu X, Van de Casteele M, Skoudy AL, Palassini M, Heimberg H, Ferrer J: Derepression of Polycomb targets during pancreatic organogenesis allows insulin-producing beta-cells to adopt a neural gene activity program.
Genome Res 20: 722-732, 2010
PubMed Abstract

Grouwels G, Cai Y, Hoebeke I, Leuckx G, Heremans Y, Ziebold U, Stangé G, Chintinne M, Ling Z, Pipeleers D, Heimberg H, Van de Casteele M: Ectopic expression of E2F1 stimulates beta cell proliferation and function.
Diabetes 59: 1435-1444, 2010
PubMed Abstract

2009

Solar M, Cardalda C, Houbracken I, Martin M, Maestro MA, De Medts N, Xu X, Grau V, Heimberg H, Bouwens L, Ferrer J: Pancreatic exocrine duct cells give rise to insulin-producing beta cells during embryogenesis but not after birth.
Dev Cell 17: 849-860, 2009
PubMed Abstract

Collombat P, Xu X, Ravassard P, Sosa-Pineda B, Dussaud S, Billestrup N, Madsen OD, Serup P, Heimberg H, Mansouri A: The Ectopic Expression of Pax4 in the Mouse Pancreas Converts Progenitor Cells into alpha and Subsequently beta Cells.
Cell 138: 449-462, 2009
PubMed Abstract

Baeyens L, Bonné S, Bos T, Rooman I, Peleman C, Lahoutte T, German M, Heimberg H, Bouwens L: Notch signaling as gatekeeper of rat acinar-to-beta cell conversion in vitro.
Gastroenterology 136:1750-1760, 2009
PubMed Abstract

Klein T, Heremans Y, Heimberg H, Pipeleers D, Madsen OD, Serup P, Heller RS: Investigation and Characterization of the Duct Cell-Enriching Process During Serum-Free Suspension and Monolayer Culture Using the Human Exocrine Pancreas Fraction.
Pancreas 38:36-48, 2009
PubMed Abstract

2008

Heimberg H: Boosting Beta-cell numbers.
N Engl J Med 359:2723-2724, 2008
PubMed Abstract

Scharfmann R, Xiao X, Heimberg H, Mallet J, Ravassard P: Beta cells within single human islets originate from multiple progenitors.
PLoS ONE 3:e3559, 2008
PubMed Abstract

Wang Q, Heimberg H, Pipeleers D, Ling Z: Glibenclamide activates translation in rat pancreatic beta cells through calcium-dependent mTOR, PKA and MEK signalling pathways.
Diabetologia 51:1202-1212, 2008
PubMed Abstract

Vandenbroucke RE, De Geest BG, Bonné S, Vinken M, Van Haecke T, Heimberg H, Wagner E, Rogiers V, De Smedt SC, Demeester J, Sanders NN: Prolonged gene silencing in hepatoma cells and primary hepatocytes after small interfering RNA delivery with biodegradable poly(beta-amino esters).
J Gene Med 10:783-794, 2008
PubMed Abstract

Cai Y, Wang Q, Ling Z, Pipeleers D, McDermott P, Pende M, Heimberg H, Van de Casteele M: Akt activation protects pancreatic beta cells from AMPK-mediated death through stimulation of mTOR.
Biochem Pharmacol 75:1981-1993, 2008
PubMed Abstract

Xu X, D'Hoker J, Stangé G, Bonné S, De Leu N, Xiao X, Van De Casteele M, Mellitzer G, Ling Z, Pipeleers D, Bouwens L, Sharfmann R, Gradwohl G, Heimberg H: Beta cell progenitors can be generated from endogenous progenitors in injured adult mouse pancreas.
Cell
132:197-207, 2008
PubMed Abstract

2007

Mfopou JK, De Groote V, Xu X, Heimberg H, Bouwens L.: Sonic hedgehog and other soluble factors from differentiating embryoid bodies inhibit pancreas development.
Stem Cells 25:1156-1165, 2007
PubMed Abstract

Hinke SA, Martens GA, Cai Y, Finsi J, Heimberg H, Pipeleers D, Van de Casteele M.: Methyl succinate antagonises biguanide-induced AMPK-activation and death of pancreatic beta-cells through restoration of mitochondrial electron transfer.
Br J Pharmacol 150:1031-1043, 2007
PubMed Abstract

Wang C, Mao R, Van De Casteele M, Pipeleers D, Ling ZD: Glucagon-like peptide-1 stimulates GABA formation by pancreatic beta-cells at the level of glutamate decarboxylase.
Am J Physiol-Endocrinol Metab 292:E1201-E1206, 2007
PubMed Abstract

Martens GA, Van de Casteele M: Glycemic control of apoptosis in the pancreatic beta cell: Danger of extremes?
Antioxid Redox Signal 9:309-317, 2007
PubMed Abstract

Grapin-Botton A, Heimberg H, Lemaigre F: The genetic programme of pancreatic beta-cells: basic science for the development of beta-cell therapy.
EMBO Rep 8:322-326, 2007
PubMed Abstract

Cai Y, Martens GA, Hinke SA, Heimberg H, Pipeleers D, Van de Casteele M: Increased oxygen radical formation and mitochondrial dysfunction mediate beta cell apoptosis under conditions of AMP-activated protein kinase stimulation.
Free Radic Biol Med
42:64-78, 2007
PubMed Abstract

2006

Rooman I, De Medts N, Baeyens L, Lardon J, De Breuck S, Heimberg H, Bouwens L.: Expression of the Notch signaling pathway and effect on exocrine cell proliferation in adult rat pancreas.
Am J Pathol
16: 1206-1214, 2006
PubMed Abstract

Harb G, Heremans Y, Heimberg H, Korbutt GS: Ectopic expression of neurogenin 3 in neonatal pig pancreatic precursor cells induces (trans)differentiation to functional alpha cells.
Diabetologia
49:1855-1863, 2006
PubMed Abstract

Mellitzer G, Bonné S, Luco, RF, Van De Casteele, M, Lenne, N, Collombat, P, Mansouri, A, Lee J, Lan M, Pipeleers D, Nielsen FC, Ferrer J, Gradwohl G. and Heimberg H.: IA1 is Ngn3-dependent and essential for differentiation of the endocrine pancreas.
EMBO J
25:1344-1352, 2006
PubMed Abstract

Wang C, Kerckhofs K, Van de Casteele M, Smolders I, Pipeleers D, Ling ZD: Glucose inhibits GABA release by pancreatic beta-cells through an increase in GABA shunt activity.
Am J
Physiol-Endocrinol Metab 290:E494-E499, 2006
PubMed Abstract

Baeyens L, Bonné S, German MS, Ravassard P, Heimberg H., Bouwens, L.: Ngn3 expression during postnatal in vitro beta cell neogenesis induced by the JAK/STAT pathway.
Cell Death Differ 13:1892-1899, 2006
PubMed Abstract

2005

Huypens P, Moens K, Heimberg H, Ling Z, Pipeleers D., Van de Casteele, M.: Adiponectin-mediated stimulation of AMP-activated protein kinase (AMPK) in pancreatic beta cells.
Life Sci 77:1273-1282, 2005
PubMed Abstract

Rescan C, Le Bras S, Hefebvre VH, Frandsen U, Klein T, Foschi M, Pipeleers DG, Scharfmann R, Madsen OD, Heimberg H: EGF-induced proliferation of adult human pancreatic duct cells is mediated by the MEK/ERK cascade.
Lab Invest 85:65-74, 2005
PubMed Abstract

Martens G, Cai Y, Hinke S, Stange G, Van De Casteele M, Pipeleers D: Nutrient sensing in pancreatic beta cells suppresses mitochondrial superoxide generation and its contribution to apoptosis.
Biochem Soc Trans
33:300-301, 2005
PubMed Abstract

Huypens P, Quartier E, Pipeleers DL, Van de Casteele M: Metformin reduces adiponectin protein expression and release in 3T3-LI adipocytes involving activation of AMP activated protein kinase.
Eur J Pharmacol 518:90-95, 2005
PubMed Abstract

Martens GA, Cai Y, Hinke S, Stange G, Van de Casteele M, Pipeleers D: Glucose suppresses superoxide generation in metabolically responsive pancreatic beta cells.
J Biol Chem 280:20389-20396, 2005
PubMed Abstract

2004

Kefas BA, Cai Y, Kerckhofs K, Ling ZD, Martens G, Heimberg H, Pipeleers D, Van de Casteele M: Metformin-induced stimulation of AMP-activated protein kinase in beta-cells impairs their glucose responsiveness and can lead to apoptosis.
Biochem Pharmacol 68:409-416, 2004
PubMed Abstract

Movahedi B, Van de Casteele M, Caluwe N, Stange G, Breckpot K, Thielemans K, Vreugdenhil G, Mathieu C, Pipeleers D: Human pancreatic duct cells can produce tumour necrosis factor-alpha that damages neighbouring beta cells and activates dendritic cells.
Diabetologia
47:998-1008, 2004
PubMed Abstract

2003

Heller RS, Klein T, Ling ZD, Heimberg H, Katoh M, Madsen OD, Serup P: Expression of Wnt, frizzled, sFRP, and DKK genes in adult human pancreas.
Gene Expr
11:141-147, 2003
PubMed Abstract

Van de Casteele M, Kefas BA, Cai Y, Heimberg H, Scott DK, Henquin JC, Pipeleers D, Jonas JC: Prolonged culture in low glucose induces apoptosis of rat pancreatic beta-cells through induction of c-myc.
Biochem Biophys Res Comm
312:937-944, 2003
PubMed Abstract

Ling ZD, Van de Casteele M, Dong J, Heimberg H, Haefliger JA, Waeber G, Schuit F, Pipeleers D: Variations in IB1/JIP1 expression regulate susceptibility of beta-cells to cytokine-induced apoptosis irrespective of C-jun NH2-terminal kinase signaling.
Diabetes 52:2497-2502, 2003
PubMed Abstract

Klein T, Ling ZD, Heimberg H, Madsen OD, Heller RS, Serup P: Nestin is expressed in vascular endothelial cells in the adult human pancreas.
J Histochem Cytochem 51:697-706, 2003
PubMed Abstract

Kefas BA, Cai Y, Ling Z, Heimberg H, Hue L, Pipeleers D, Van de Casteele M: AMP-activated protein kinase can induce apoptosis of insulin-producing MIN6 cells through stimulation of c-Jun-N-terminal kinase.
J Mol Endocrinol
30:151-161, 2003
PubMed Abstract

Kefas BA, Heimberg H, Vaulont S, Meisse D, Hue L, Pipeleers D, Casteele M: AICA-riboside induces apoptosis of pancreatic beta cells through stimulation of AMP-activated protein kinase.
Diabetologia
46:250-254, 2003
PubMed Abstract

2002

Heremans Y, Van De Casteele M, in 't Veld P, Gradwohl G, Serup P, Madsen O, Pipeleers D, Heimberg H: Recapitulation of embryonic neuroendocrine differentiation in adult human pancreatic duct cells expressing neurogenin 3.
J Cell Biol 159:303-311, 2002
PubMed Abstract

Van de Casteele M, Kefas BA, Ling ZD, Heimberg H, Pipeleers DG: Specific expression of Bax-omega in pancreatic beta-cells is down-regulated by cytokines before the onset of apoptosis.
Endocrinology
143:320-326, 2002
PubMed Abstract

2001

Cardozo AK, Heimberg H, Heremans Y, Leeman R, Kutlu B, Kruhoffer M, Orntoft T, Eizirik DL: A comprehensive analysis of cytokine-induced and nuclear factor-kappa B-dependent genes in primary rat pancreatic beta-cells.
J Biol Chem
276:48879-48886, 2001
PubMed Abstract

Heimberg H, Heremans Y, Jobin C, Leemans R, Cardozo AK, Darville M, Eizirik DL: Inhibition of cytokine-induced NF-kappa B activation by adenovirusmediated expression of a NF-kappa B super-repressor prevents beta-cell apoptosis.
Diabetes 50:2219-2224, 2001
PubMed Abstract

Schuit FC, Huypens P, Heimberg H, Pipeleers DG: Glucose sensing in pancreatic beta-cells - A model for the study of other glucose-regulated cells in gut, pancreas, and hypothalamus.
Diabetes
50:1-11, 2001
PubMed Abstract

Pipeleers D, Hoorens A, Marichal-Pipeleers M, Van de Casteele M, Bouwens L, Ling ZD: Role of pancreatic beta-cells in the process of beta-cell death.
Diabetes
50:S52-S57, 2001
PubMed Abstract

2000

Rooman I, Heremans Y, Heimberg H, Bouwens L: Modulation of rat pancreatic acinoductal transdifferentiation and expression of PDX-1 in vitro.
Diabetologia
43:907-+, 2000
PubMed Abstract

Rochlitz H, Voigt A, Lankat-Buttgereit B, Goke B, Heimberg H, Nauck MA, Schiemann U, Schatz H, Pfeiffer AFH: Cloning and quantitative determination of the human Ca2+/calmodulin-dependent protein kinase II (CaMK II) isoforms in human beta cells.
Diabetologia 43:465-473, 2000
PubMed Abstract

Heimberg H, Bouwens L, Heremans Y, Van De Casteele M, Lefebvre V, Pipeleers D: Adult human pancreatic duct and islet cells exhibit similarities in expression and differences in phosphorylation and complex formation of the homeodomain protein Ipf-1.
Diabetes
49:571-579, 2000
PubMed Abstract

Ling ZD, Van de Casteele M, Eizirik DL, Pipeleers DG: Interleukin-1 beta- induced alteration in a beta-cell phenotype can reduce cellular sensitivity to conditions that cause necrosis but not to cytokine-induced apoptosis.
Diabetes 49:340-345, 2000
PubMed Abstract

1999

Schuit F, Moens K, Heimberg H, Pipeleers D: Cellular origin of hexokinase in pancreatic islets.
J Biol Chem 274:32803-32809, 1999
PubMed Abstract

Heimberg H: Transcription factors in developing endocrine pancreas.
Ann Endocrinol
60:249-250, 1999

1998

Ling ZD, Heimberg H, Foriers A, Schuit F, Pipeleers D: Differential expression of rat insulin I and II messenger ribonucleic acid after prolonged exposure of islet beta-cells to elevated glucose levels.
Endocrinology
139:491-495, 1998
PubMed Abstract

1997

Schuit FC, De Vos A, Moens K, Quartier E, Heimberg H: Glucose-induced B-cell recruitment and the expression of hexokinase isoenzymes. In Physiology and Pathophysiology of the Islets of Langerhans, 1997, p. 259-266

Ferber S, Heimberg H, Brownlee M, Colton C: Surrogate beta cells.
Diabetologia
40:B39-B43, 1997

1996

Heimberg H, De Vos A, Moens K, Quartier E, Bouwens L, Pipeleers D, Van Schaftingen E, Madsen O, Schuit F: The glucose sensor protein glucokinase is expressed in glucagon-producing alpha-cells.
Proc Natl
Acad Sci USA 93:7036-7041, 1996
PubMed Abstract

Moens K, Heimberg H, Flamez D, Huypens P, Quartier E, Ling ZD, Pipeleers D, Gremlich S, Thorens B, Schuit F: Expression and functional activity of glucagon, glucagon-like peptide I, and glucose-dependent insulinotropic peptide receptors in rat pancreatic islet cells. Diabetes 45:257-261, 1996
PubMed Abstract

Hoorens A, Van De Casteele M, Klöppel G, Pipeleers D: Glucose promotes survival of rat pancreatic beta cells by activating synthesis of proteins which suppress a constitutive apoptotic program.
J Clin Invest 98:1568-1574, 1996
PubMed Abstract

1995

Devos A, Heimberg H, Quartier E, Huypens P, Bouwens L, Pipeleers D, Schuit F: Human and Rat Beta-Cells Differ in Glucose-Transporter but Not in Glucokinase Gene-Expression. J Clin Invest 96:2489-2495, 1995
PubMed Abstract

Van der Auwera B, Van Waeyenberge C, Schuit F, Heimberg H, Vandewalle C, Gorus F, Flament J: DRB1*0403 Protects against IDDM in Caucasians with the High-Risk Heterozygous DQA1*0301-DQB*0302/DQA1*0501-DQB1*0201 Genotype.
Diabetes
44:527-530, 1995
PubMed Abstract

Heimberg H, De Vos A, Pipeleers D, Thorens B, Schuit F: Differences in Glucose-Transporter Gene-Expression between Rat Pancreatic Alpha-Cells and Beta-Cells Are Correlated to Differences in Glucose-Transport but Not in Glucose-Utilization.
J Biol Chem 270:8971-8975, 1995
PubMed Abstract

Bouwens L, Braet F, Heimberg H: Identification of Rat Pancreatic Duct Cells by Their Expression of Cytokeratin-7, Cytokeratin-19, and Cytokeratin-20 in-Vivo and after Isolation and Culture.
J
Histochem Cytochem 43:245-253, 1995
PubMed Abstract

1993

Heimberg H, De Vos A, Vandercammen A, Vanschaftingen E, Pipeleers D, Schuit F: Heterogeneity in Glucose Sensitivity among Pancreatic Beta-Cells Is Correlated to Differences in Glucose Phosphorylation Rather Than Glucose- Transport.
EMBO J
12:2873-2879, 1993
PubMed Abstract

Van der Auwera BJ, Heimberg H, Schrevens AF, Van Waeyenberge C, Flament J, Schuit FC: 5' Insulin Gene Polymorphism Confers Risk to IDDM Independently of HLA Class-Ii Susceptibility.
Diabetes 42:851-854, 1993
PubMed Abstract

1992

Heimberg H, Nagy ZP, Somers G, De Leeuw I, Schuit FC: Complementation of HLA-DQA and HLA-DQB Genes Confers Susceptibility and Protection to Insulin- Dependent Diabetes-Mellitus.
Human Immunol 33:10-17, 1992
PubMed Abstract

 

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